Which of the following conditions can lead to an increased risk of infection?

The option indicating a compromised defense is correct because a weakened immune system or any condition that impairs the body’s natural defenses can significantly elevate the risk of infection. When the body's ability to fight off pathogens is hindered, whether due to chronic illness, malnutrition, or other factors, it becomes more susceptible to infections. This is especially critical in healthcare settings where the presence of microorganisms is high, and individuals with compromised immune systems are unable to effectively eliminate these threats.

In contrast, a strong immune system, healthy lifestyle choices, and effective hand hygiene actively work to reduce the risk of infections. A strong immune system functions efficiently to combat pathogens, a healthy lifestyle promotes overall well-being and resilience against diseases, and practicing effective hand hygiene dramatically lowers the transmission of infectious agents. Each of these factors enhances the body's defenses, making it less likely to develop infections.